Interstitial cystitis (IC) is a chronic condition that causes bladder pain and discomfort. Symptoms of IC may include a feeling of pressure in the bladder, an urgent need to urinate, and pain in the lower abdomen or bladder area. Diagnosis of IC is made through a combination of medical history, physical exam, and other tests. Treatment for IC includes lifestyle changes, medications, bladder instillations, and surgery. Lifestyle changes may include reducing caffeine and acidic foods, avoiding activities that can irritate the bladder, and practicing relaxation techniques. Medications used to treat IC may include oral antihistamines, tricyclic antidepressants, and pentosan polysulfate sodium. Bladder instillations involve filling the bladder with a solution of either heparin or dimethyl sulfoxide, which helps reduce inflammation. Surgery may be used in severe cases and involves removing the bladder lining to reduce pain and discomfort.